Figure 3. Effect of RvD1 on the expression of IL-1β and IL-18 in STZ-treated rats. A: Retinal expression of interleukin-1 beta (IL-1β) was increased in the streptozotocin (STZ)-treated group compared with the control groups but decreased after injection of resolvin D1 (RvD1). B: The protein expression of IL-18 was statistically significantly upregulated in the retinas of the STZ group and the vehicle group compared with the control group and reduced in the RvD1 group. C: The mRNA expression of IL-1β in the retina was increased in the STZ and vehicle groups compared with the control group while reduced by injection of RvD1 in the RvD1 group. D: The mRNA expression of IL-18 in the retina was markedly increased in the STZ group and the vehicle group compared with the control group. However, the level of mRNA expression was decreased by intravitreal injection of RvD1. * p<0.05, ** p<0.01, *** p<0.001. Values are expressed as mean ± standard deviation (SD); n = 6 experiments.