Table 2 of Zhang, Mol Vis 2017; 23:228-241.

Table 2. RPE abnormalities in Atg5ΔRPE and Atg7ΔRPE mice.

Genotype Atg5ΔRPE Atg7ΔRPE
Retinal degeneration - + - +
Vacuoles 8–12 months + + + +
13–18 months + + + +
19–24 months + + + +
Uneven RPE thickness 8–12 months - + - +
13–18 months + + + +
19–24 months + + + +
Loss of basal infoldings 8–12 months - + - +
13–18 months + + + +
19–24 months + + + +
Hypertrophy / hypotrophy 8–12 months - + - +
13–18 months + + + +
19–24 months + + + +
Pigmentary irregularities 8–12 months - + - +
13–18 months + + + +
19–24 months + + + +
Necrosis 8–12 months - + - +
13–18 months + + + +
19–24 months + + + +

RPE abnormalities observed in Atg5ΔRPE and Atg7ΔRPE mice aging from 8 to 24 months were classified into six categories. “-“ indicates no difference between Atg5ΔRPE/Atg7ΔRPE and age-matched wild-type control mice; and “+” indicates abnormalities in Atg5ΔRPE or Atg7ΔRPE mice

Zhang, Mol Vis 2017; 23:228-241. http://www.molvis.org/molvis/v23/228

©2017 Molecular Vision http://www.molvis.org/molvis/

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