Figure 7. Thinned RPE in aged Atg5^ΔRPE and Atg7^ΔRPE mice. Representative electronic micrographs showing the RPE region of the 17-month-old wild-type (+/+), Atg5^ΔRPE (Atg5−/−), and Atg7^ΔRPE (Atg7−/−) mice. Note that the RPE thicknesses of the Atg5^ΔRPE and Atg7^ΔRPE mice are approximately one third to one half that of the wild-type mice. The wild-type and Atg5^ΔRPE mice shown were pigmented, and the Atg7^ΔRPE mouse was albino. Arrow indicates a hypotrophic RPE cell. Scale bar = 10 µm.