Figure 5. Retinal degeneration in aged Atg5^ΔRPE and Atg7^ΔRPE mice. Representative images of toluidine blue–stained sections showing the retina layers of 17-month-old wild-type, Atg5^ΔRPE, and Atg7^ΔRPE mice. Note the retina layers of the Atg5^ΔRPE and Atg7^ΔRPE mice without retinal degeneration (no rd) were similar to those of the wild-type mice but the outer plexiform layer (OPL), ONL, IS, and OS were diminished in the Atg5^ΔRPE and Atg7^ΔRPE mice with retinal degeneration (rd). The image for the Atg7^ΔRPE mice without retinal degeneration was from a pigmented background, and the other images were from albino mice. Arrows indicate engorged RPE cells. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer.