Figure 3. Lrp5^tvrm111B mutant mice exhibit reduced bone mass. A: Whole-body areal bone mineral density (aBMD) is reduced in Lrp5^tvrm111B mutant mice as compared to controls. B: This likely resulted from a decrease in bone mineral content (BMC), not a reduction in bone area (not shown). These results remained significant after correction for total tissue mass (not shown). Bars indicate average ± standard error of the mean (SEM) of five mice per group.