Figure 4. Relationship between fungal keratitis and NET formation. A: Slit-lamp microscopy observation of the cornea and the anterior chamber shows that the corneal ulcer healed after a cure
course of a 15-day treatment in the patient infected with Candida albicans in whom the number of neutrophil extracellular traps (NETs) was rated “++” with immunofluorescence. B: A longer cure course of treatment of 21 days was needed for another patient infected with Fusarium solani in whom the number of NETs rated “+.” C: A higher number of NETs is closely related to a better treatment response and a shorter course of infection. Data represent
mean ± standard deviation (SD), r = –0.891, p<0.001 by Kendall tau_b correlation test. Bar: 100 μm.