Table 4 of Tang, Mol Vis 2016; 22:917-932.


Table 4. Phenotype-genotype analysis in modified classification system.

Group Phenotypes N. Age at diagnosis Gender M(M%) N. of pathogenic FZD4 mutations
I: Mild Bilateral asymptomatic but confirmed by FFA 10(10.0%) 44.0±15.1 4(40.0%) 0
II: Moderate Vitreous hemorrhage due to RNV* 4(4.0%) 25.3±12.3 2(50.0%) 1
III: Severe Retinal folding or ectopic macula* 69(69.0%) 9.2±10.3 57(82.6%) 20
IV: Extreme severe Total tractional RD in infancy* 17(17.0%) 2.0±2.3 14(82.3%) 0
P value - - <0.001 0.012§ -
  Total 100(100%) 12.1±15.3 77(77.0%) 21