Figure 4. Schematic pedigrees of the families with mutations in
FZD4. Arrows indicate proband; open symbols: clinically unaffected; solid symbols: clinically affected; +: clinically evaluated;
+/−: heterozygous with familial mutation; −/−, wild-type. For the mutations in
FZD4, the nomenclature is based on GenBank
NM_012193.2.