Table 3 of
Chen, Mol Vis 2016; 22:783-796. Table 3 of
Chen, Mol Vis 2016; 22:783-796.
Table 3. Association results for genetic variants in published GWAS loci for spherical equivalent or myopia.
| Loci | Gene | GWAS variantsb | GWAS effect size | Tested variant (r2)c | MAF | β (SE) | P value |
|---|---|---|---|---|---|---|---|
| Spherical equivalent | |||||||
| 14q23.1 | SIX6 [30] | rs1254319 | −0.09 | rs1254319 (1.00) | 29% [A] | −0.17 (0.10) | >0.01 |
| 15q14 | GJD2 [31] | rs634990 | −0.23 | rs634990 (1.00) | 47% [C] | −0.29 (0.09) | 1.8 × 10−3 |
| 15q24.2 | RASGRF1 [32] | rs939658 | −0.15 | rs939658 (1.00) | 50% [A] | −0.04 (0.10) | >0.01 |
| 18q22.3 | CNDP2 [30] | rs12971120 | 0.11 | rs2278161 (1.00) | 22% [C] | 0.14 (0.12) | >0.01 |
| Myopia | |||||||
|---|---|---|---|---|---|---|---|
| 2q31.2 | PDE11A [34] | rs17400325 | 1.14d | rs17400325 (1.00) | 3% [C] | −0.15 (0.28) | >0.01 |
| 2q37.1 | PRSS56 [34] | rs1550094 | 1.09d | rs1550094 (1.00) | 31% [G] | −0.33 (0.10) | 1.7 × 10−3 |
| 4q25 | 4q25 [24] | rs10034228 | 0.81e | rs10034228 (1.00) | 31% [C] | −0.02 (0.10) | >0.01 |
| 13q12 | MIPEP [26] | rs9318086 | 1.64/1.32f | rs9318086 (1.00) | 44% [A] | −0.03 (0.10) | >0.01 |