Figure 1. Manhattan plot for the single-variant association results. A total of 34,976 variants with minor allele frequency (MAF) ≥1.0% were tested for single-variant associations. The significance threshold across the exome was set to p<2.1×10⁻⁶ (red line). Suggestive associations were discovered on two variants in the TCTE1 gene region at 6p21.1: rs2297336 (p = 3.7 ×10⁻⁶) and rs324146 (p = 1.4 ×10⁻⁵).