Figure 7. Regional evaluation of the collagen structure. Pooled statistics (linear mixed model for repeated measures) showing comparison of the collagen structure within peripapillary (PPS) and mid-posterior (MPS) scleral regions between the carrier and affected ADAMTS10 mutant posterior canine scleras. A: A marginal but significant reduction in collagen anisotropy was measured in the mid-posterior scleral region for the affected group. B: The marked visible reduction in collagen density within both scleral regions of the affected specimens was statistically confirmed. Error bars: standard deviation.