Figure 5. Association of 381 variable positions on mtDNA with POAG in African-Americans. The number of individuals estimated to differ from the rCRS reference sequence in the POAG case pool (n=1,217) was compared to the number of estimated variant individuals in the control pool (n=782) for each variable position, the significance of the predicted difference was assessed using a Chi-square test, and the negative log₁₀ of the resulting p value is plotted. Variable positions annotated as having a disease association in MITOMAP or as “pathogenic” or “likely pathogenic” by the NCBI variant viewer are indicated by markers with solid red fill. Selected markers are identified by their coordinates on the rCRS reference sequence.