Table 3 of
Akin, Mol Vis 2016; 22:40-60. Table 3 of
Akin, Mol Vis 2016; 22:40-60.
Table 3. Gene Ontology of genes upregulated in response to PNN reduction.
| GO term | Description | P-value | FDR q-value | Enrichment | Genes |
|---|---|---|---|---|---|
| Biologic Process | |||||
| GO:0030334 | regulation of cell migration | 3.28E-08 | 3.79E-04 | 3.73 | MMP10, EGFR, CXCL3, MMP9, STC1, CXCL1, UNC5C, HAS2, CXCL2, TRIB1, STRAP, LAMA3 |
| GO:0006520 | cellular amino acid metabolic process | 9.41E-08 | 5.44E-04 | 4.8 | EGLN1, PSAT1, PLA2G4E, GARS, MTHFD2L, GLS |
| GO:0030198 | extracellular matrix organization | 1.03E-07 | 3.98E-04 | 5.09 | MMP13, MMP1, MMP10, MYO1E, ANXA2, MMP9, SERPINb5, CD44, LAMC!, HAS2, LAMC2, LAM3 |
| GO:0043062 | extracellular structure organization | 1.03E-07 | 2.98E-04 | 5.09 | MMP1, TIMP1, ACTN1. LAMC2, MMP13, TNC, SERPINB5, CD47, CD44, MMP9, ITGA2, SDC4 |
| Molecular Function | |||||
| GO:0044822 | poly(A) RNA binding | 2.03E-09 | 6.63E-06 | 1.63 | UBC, ANXA2, NQo1, NAA38, RPS16, RRP12, STRAP |
| GO:0045236 | CXCR chemokine receptor binding | 2.18E-08 | 2.37E-05 | 64.04 | CXCL3, CXCL1, CXCL2, YARS |
| GO:0004222 | metalloendopeptidase activity | 1.27E-06 | 1.03E-03 | 25.32 | MMP10, ADAMS6, ADAM19, MMP13, MMP1, MMP9 |