Figure 3. The Th17 transfer EAE model exhibits more severe motor and vision deficits relative to Th1. A: Daily mean experimental autoimmune encephalomyelitis (EAE) severity scores for Th1 (red circles) and Th17 (blue squares)
transfer EAE mice. B, C: Daily mean acuity of more (B) or less (C) affected eyes of Th1 (red circles) and Th17 (blue squares) mice as measured by optokinetic reflex (OKT) where the more affected
eye of each mouse is classified as that with the lower average OKT value over the course of the study. Error bars represent
standard error of the mean (SEM). Number of eyes: n = 15 for −1–7 days post-immunization (DPI), n = 10 for 8–12 DPI, and n
= 5 for 13–21 DPI. *p<0.05; **p<0.005 with the linear mixed effect model.