Molecular Vision: Ahmed, Mol Vis 2016; 22:294-310. Table 3

Table 3. Xaliproden administration by oral gavage induces antioxidant response in mouse retina.

Target gene	Relative expression (versus β-actin) ± SD.		Fold induction	P value
Target gene	Saline	Xaliproden	Fold induction	P value
HO-1	2.91±0.68	11.4±3.6	3.9	0.01
GSTM-1	46.64±16	163.7±30.3	3.5	0.002
NqO-1	0.66±0.23	2.5±0.67	3.8	0.007
CAT	39.88±11.5	63.0±14	1.58	0.03
Met-1	77.45±12.3	301±34	3.88	0.007

Mice (C57BL/6, 4 −6 weeks old, n=5) were given xaliproden (3 mg/kg), or saline as control by oral gavage once daily for four days. On fourth day, eyes were enucleated, dissected obtain the retina. RNA was extracted and used to carry out qPCR for the antioxidant genes expression relative to β-actin. Values represent average fold change over the saline treated mice (both relative to β-actin) ± SD. Abbrev: HO-1, heme oxygenase; GSTM1, glutathione S-transferase Mu-1; NqO-1, NAD(P)H dehydrogenase Mu-1; CAT, catalase, Met-1, metallothionein-1. P values were determined using Student t test for unpaired samples.