Figure 9. Damage from RPE oxidative stress is reduced by treatment with xaliproden. Electron micrographs of eyes of Sod2^loxP/loxP RPE-cre mice treated for 4 months with (A) vehicle, with (B) 0.5 mg/kg xaliproden, or with (C) 3.0 mg/kg xaliproden. Vacuoles apparent in the RPE and photoreceptor outer segments of control mice (A) are largely absent in the xaliproden-treated mice (B and C). Original magnification 2,000X; scale bar = 10 μm.