Figure 10. RPE vacuolization is mitigated by xaliproden. Electron micrographs of eyes from mice treated for of Sod2^loxP/loxP RPE-cre mice treated for 4 months with (A) vehicle, with (B) 0.5 mg/kg xaliproden, or with (C) 3.0 mg/kg xaliproden. The unfolding of the basal structure of the RPE and the large vacuoles in the RPE present in vehicle-treated eyes (A) is reduced in the eyes of animals fed with xaliproden. Original images 5,000X, scale bar = 2 μm.