Figure 5. EEDK promotes expression of Ki-67. Representative immunohistochemical staining images of the cornea were stained with Ki-67 antibody (Brown: Ki-67-positive cells) and obtained with light microscopy (original magnification, 400X). A: The control group. B: The dry eye (DE) group. C: The 50 mg/kg ethanol extract of Diospyros kaki (EEDK)-treated group. D: The 10 mg/kg EEDK-treated group. E: The positive-control group (Refresh Plus, preservative-free eye drops, Allergan). An arrow indicates proliferating epithelial cells. Scale bar = 50 μm. The results shown are representative of three independent experiments (n = 8 mice per group).