Figure 2. High IOP and TID phenotypes differ in age of peak phenotype expression. A: Intraocular pressure (IOP) values increased with age until the 6- to 9-month-old cohort and then progressively decreased
in the older cohorts. The mean IOP values ranged between 14.14±0.42 (the >13-month-old cohort) and 16.48±0.29 mmHg (the 6-
to 9-month-old cohort) across the BXD mice. Heritability of the IOP phenotype ranged between 28.07% and 39.87%, with the highest
values obtained in the oldest cohort. B: The transillumination defects (TIDs) increased progressively with age. The average TID grade ranged between 0.71±0.10 (the
1- to 2-month-old cohort) and 1.29±0.15 (the >13-month-old cohort). The heritability of the TID phenotype ranged between 88.59%
and 97.22%, with the highest values obtained in the 10- to 13-month-old cohort.