Figure 1. Elevated IOP phenotype in BXD mice is independent of circadian rhythms. A: The intraocular pressure (IOP) values in the B6 mice ranged between 15.1±0.3 and 15.5±0.2 mmHg and did not differ significantly between 8 AM and 6 PM (p>0.05; n = 5 mice at each time of day). B: The elevated IOP phenotype in the BXD mice is independent of sidedness. Within each age cohort, no significant difference was observed between the right and left eyes (p>0.05; the n values, superimposed on each bar of the graph, represent the number of mice). C: The elevated IOP phenotype in BXD mice is independent of gender. Within each age group, no significant differences were observed between female and male mice (p>0.05; the n values, superimposed on each bar of the graph, represent the number of mice).