Figure 1. Nrf2-deficient female mice exhibited more severe EAE-associated motor deficits compared with the wild-type mice. A–D: Daily mean experimental autoimmune encephalomyelitis (EAE) motor severity scores for wild-type (WT) male mice (aqua circles), WT female mice (orange squares), knockout (KO) male mice (green triangles), and KO female mice (purple upside-down triangles). Error bars represent the standard error of the mean (SEM); n = 4–6 mice per genotype per gender pooled from two independent experiments. *p<0.05, **p<0.005, ***p<0.001 by the linear mixed-effects model.