Figure 1. GLE decreased relative expression of Nrl, Nr2e3, Crx, and Rho genes. In the control and GLE retinas, the developmental patterns of (A) Nrl, (B) Nr2e3, (C) Crx, and (D) Rho gene expression were similar, and their relative gene expression significantly increased from E16.5 to PN10. A: In the GLE retinas, Nrl expression significantly decreased at PN2 and PN6 relative to the age-matched controls. B–D: In the GLE retinas, Nr2e3, Crx, and Rho expression significantly decreased at PN2 relative to the age-matched controls. The mean ± SEM values represent the triplicate samples from four to five animals per treatment group per age. Values with an asterisk indicate p < 0.05 compared to the controls. GLE = Gestational lead exposure; E = embryonic; PN = postnatal; SEM = standard error of the mean.