Figure 6. Inhibition of Islet-1 and VEGF expression in murine retinas by siRNA targeting Islet-1. Real-time PCR and western blot analysis for Islet-1 and the vascular endothelial growth factor (VEGF) level in murine retinas. The level of Islet-1 and VEGF in the murine retinas was decreased after local administration of Islet-1 siRNA compared to the model of oxygen-induced retinopathy (OIR) (★p<0.05). A: Room air–raised mice. B: The murine OIR model injected with siRNA targeting Islet-1. C: The murine OIR model with injection of negative control siRNA. D: The murine model of OIR.