Figure 5. Sequence chromatography from Sanger sequencing. Mutations in ARR3 identified with whole exome sequencing were further confirmed with Sanger sequencing and then validated in family members. The sequence with heterozygous mutations detected in female patients with early onset high myopia (eoHM) are shown on the left, whereas the corresponding normal sequences from controls are shown on the right. Arrows indicate the sites with and without mutations in the patients and controls, respectively.