Figure 3. Family XF3 demonstrating haplotypes around ARR3 and mutation segregation with eoHM. Filled circles represent female family members affected with early onset high myopia (eoHM). IV:1 is the proband. The novel c.239T>C (p.Leu80Pro) mutation in ARR3 was present in all four female patients examined. One male family member with the mutation (V:1) did not have eoHM. Except the mutation, genotyping information for microsatellite markers around ARR3 was not available for V:2 because she was recently added. M: mutation; +: Normal allele.