Figure 2. Family XF2 demonstrating haplotypes around ARR3 and mutation segregation with eoHM. Filled circles represent female family members affected with early onset high myopia (eoHM). III:10 was the proband. The novel c.298C>T (p.Arg100*) mutation in ARR3 was present in all ten female patients examined. M: mutation; +: Normal allele.