Figure 1. Family XF1 demonstrating haplotypes around ARR3 and mutation segregation with eoHM. Filled circles represent female family members affected with early onset high myopia (eoHM). V:12 is the proband. The novel c.893C>A (p.Ala298Asp) mutation in ARR3 was present in 15 female patients examined in this family but not in unaffected female family members. Two male family members with mutations (III:1 and III:3) and one obligate male carrier (II:3) did not have eoHM. M: mutation; +: Normal allele.