Table 2 of
Kosior-Jarecka, Mol Vis 2016; 22:1256-1266. Table 2 of
Kosior-Jarecka, Mol Vis 2016; 22:1256-1266.
Table 2. Distribution of the genotypes and alleles of endothelin-1 (EDN1) and endothelin receptor type A (EDN RA) polymorphisms in primary open-angle glaucoma (NTG and HTG) and healthy controls.
| Gene/Polymorphism | ||||||||
|---|---|---|---|---|---|---|---|---|
| EDN-1: K198N | ||||||||
| Genotype | NTG+HTG | Controls | P value | OR (95% CI) | P value | Allele frequencies | P value | |
| GG | 198 | 125 | 0.27 | 0.77 (0.47–1.14) | 0.170 | allele G | allele T | 0.115 |
| TT | 11 | 3 | 2.17 (0.59–1.91) | 0.230 | 471 | 97 | ||
| GT | 75 | 37 | 1.24 (0.79–1.94) | 0.340 | 287 | 43 | ||
| EDN RA: C1222T | ||||||||
| Genotype | NTG+HTG | Controls | P value | OR (95% CI) | P value | Allele frequencies | P value | |
| CC | 100 | 55 | 0.035 | 1.09 (0.73–1.64) | 0.660 | allele C | allele T | 0.074 |
| TT | 40 | 39 | 0.53 (0.33–0.87) | 0.011 | 343 | 223 | ||
| CT | 143 | 71 | 1.35 (0.92–1.99) | 0.125 | 181 | 149 | ||
| EDN RA: C70G | ||||||||
| Genotype | NTG+HTG | Controls | P value | OR (95% CI) | P value | Allele frequencies | P value | |
| CC | 48 | 48 | 0.001 | 0.50 (0.32–0.8) | 0.003 | allele C | allele G | 0.174 |
| GG | 80 | 51 | 0.85 (0.56–1.29) | 0.446 | 252 | 316 | ||
| CG | 156 | 63 | 1.92 (1.29–2.84) | 0.001 | 159 | 165 | ||
| EDN RA: G231A | ||||||||
| Genotype | NTG+HTG | Controls | P value | OR (95% CI) | P value | Allele frequencies | P value | |
| GG | 148 | 81 | 0.073 | 1.13 (0.77–1.66) | 0.537 | allele G | allele A | 0.180 |
| AA | 11 | 15 | 0.4 (0.18–0.90) | 0.026 | 421 | 147 | ||
| GA | 125 | 69 | 1.09 (0.74–1.61) | 0.650 | 231 | 99 | ||