Figure 5 of Shao, Mol Vis 2016; 22:1188-1197.


Figure 5. TTR modulated the expression of several genes for NV development in hRECs. In the natural medium (LG) with TTR, the VEGFR1, VEGFR2, Tie2, and Angpt2 levels were all upregulated, while Angpt1 was unchanged. In the LG+Hypoxia medium with TTR, Tie2 and VEGFR1 were downregulated, while VEGFR2, Angpt1, and Angpt2 were all upregulated. In the hyperglycemia (HG) medium with TTR, Tie2 and Angpt1 were significantly upregulated, while Angpt2, VEGFR1, and VEGF2 were dramatically decreased. In the HG+Hypoxia medium with TTR, Tie2 and Angpt1 were upregulated, whereas Angpt2, VEGFR1, and VEGF2, were downregulated.