Table 3 of
Sardell, Mol Vis 2016; 22:1062-1076. Table 3 of
Sardell, Mol Vis 2016; 22:1062-1076.
Table 3. Details of the most strongly associated damaging exonic variants from Firth association test controlling for age and sex. P values of variants from exome-chip analysis of 33,976 cases and controls are also reported [36].
| Rs ID | Position | Minor/major allele | MAF cases | MAF controls | β | P-value | Nearest gene | Exome chip p value |
|---|---|---|---|---|---|---|---|---|
| rs2294066 | 8:2046700 | T/C | 0.18 | 0.04 | 2.71 | 1.32×10−4 | MYOM2 | 0.73 |
| rs440160 | 6:32023903 | C/G | 0.13 | 0.01 | 2.78 | 1.36×10−3 | TNXB* | 4.28×10−29 |
| rs61739424 | 5:177683905 | A/G | 0.08 | 0 | 3.70 | 2.28×10−3 | COL23A1 | 0.87 |
| rs61738888 | 3:33728610 | G/A | 0.18 | 0.04 | 2.01 | 2.58×10−3 | CLASP2 | 0.93 |
| rs3735099 | 7:2472429 | A/C | 0 | 0.13 | −3.50 | 2.68×10−3 | CHST12 | 0.26 |
| rs73210702 | 3:128751670 | A/G | 0 | 0.07 | −3.60 | 2.92×10−3 | EFCC1 | 0.26 |
| rs117615621 | 17:4455266 | T/G | 0 | 0.06 | −3.78 | 2.97×10−3 | MYBBP1A | 0.18 |
| rs141133909 | 6:74161604 | T/C | 0.08 | 0 | 3.93 | 3.12×10−3 | MB21D1 | 0.23 |
| rs12138972 | 1:182873431 | T/C | 0 | 0.08 | −3.52 | 3.28×10−3 | SHCBP1L | 0.89 |
| rs1034405 | 3:50597092 | G/A | 0.19 | 0.06 | 1.88 | 3.77×10−3 | C3orf18 | 0.11 |
| rs2236200 | 20:60986019 | C/A | 0.13 | 0.33 | −1.39 | 3.78×10−3 | RBBP8NL | 0.09 |
| rs59371099 | 22:29885016 | A/G | 0.13 | 0.03 | 2.33 | 3.87×10−3 | NEFH | 0.58 |
| rs35012290 | 4:47538044 | A/G | 0.15 | 0.01 | 2.32 | 4.00×10−3 | ATP10D | 0.94 |
| rs11036815 | 11:5344681 | A/G | 0.23 | 0.42 | −1.26 | 4.29×10−3 | OR51B2 | 0.33 |
| rs10951942 | 7:48081095 | T/G | 0.32 | 0.56 | −1.33 | 4.55×10−3 | C7orf57 | 0.01 |
| rs754511 | 20:33575677 | A/T | 0 | 0.04 | −3.65 | 4.83×10−3 | MYH7B | 0.65 |
| rs12225230 | 11:116728630 | C/G | 0.31 | 0.11 | 1.41 | 4.92×10−3 | SIK3 | 0.06 |
| rs3818551 | 10:29581493 | C/A | 0.08 | 0.25 | −1.51 | 4.95×10−3 | LYZL1 | 0.12 |
| *prior AMD locus | ||||||||