Table 2 of
Sardell, Mol Vis 2016; 22:1062-1076. Table 2 of
Sardell, Mol Vis 2016; 22:1062-1076.
Table 2. The most strongly associated single variants (p<1×10−4) from Firth logistic regression controlling for age and sex. P values for single variants from exome-chip analysis of 33,976 cases and controls are also reported [36].
| rs ID | Position | Minor/major allele | MAF cases | MAF controls | β | P-value | Nearest gene | Exome chip p-value |
|---|---|---|---|---|---|---|---|---|
| rs2274700 | 1:196682947 | A/G | 0.58 | 0.10 | 3.89 | 3.89×10−10 | CFH* | 3.89×10−612 |
| 10:124216823 | T/G | 0.05 | 0.50 | −3.30 | 4.28×10−8 | ARMS2* ARMS2* ARMS2* ARMS2* | NA | |
| rs369830546 | 10:124216828 | T/G | 0.05 | 0.47 | −3.16 | 1.57×10−7 | NA | |
| rs375465540 | 10:124216827 | T/G | 0.05 | 0.47 | −3.19 | 1.72×10−7 | NA | |
| 10:124216829 | A/C | 0.05 | 0.47 | −3.19 | 1.72×10−7 | NA | ||
| rs4849050 | 2:112939548 | C/T | 0.03 | 0.29 | −3.41 | 1.74×10−6 | FBLN7 | 0.13 |
| rs1106797 | 21:45170285 | A/G | 0.14 | 0.43 | −2.26 | 3.93×10−5 | PDXK | 0.24 |
| rs8133485 | 21:45180338 | A/G | 0.14 | 0.44 | −2.22 | 4.65×10−5 | LOC101928493/PDXK | 0.17 |
| rs8130574 | 21:45180422 | G/A | 0.14 | 0.44 | −2.22 | 4.65×10−5 | LOC101928493/PDXK | 0.18 |
| rs3209790 | 2:163217812 | T/C | 0.14 | 0.03 | 3.44 | 4.74×10−5 | GCA | 0.34 |
| rs2272551 | 14:22690209 | A/C | 0.22 | 0.04 | 2.69 | 4.93×10−5 | OR4E2,DAD1 | 0.60 |
| rs2857766 | 6::29634003 | C/G | 0.13 | 0.40 | −2.10 | 7.45×10−5 | MOG | 0.30 |
| rs1318631 | 6:29635508 | A/G | 0.13 | 0.40 | −2.10 | 7.45×10−5 | MOG | 0.29 |
| rs4849005 | 2:112854584 | G/A | 0.01 | 0.19 | −3.31 | 7.64×10−5 | TMEM87B | 0.08 |
| rs7538954 | 1:200967778 | T/G | 0.23 | 0.06 | 2.64 | 7.72×10−5 | KIF21B | 0.74 |
| rs35857370 | 9:139354097 | A/G | 0.34 | 0.09 | 2.03 | 7.97×10−5 | SEC16A | 0.98 |
| rs12673849 | 7:149562275 | T/C | 0.09 | 0 | 4.53 | 9.48×10−5 | ZNF862 | 0.33 |
| rs117051141 | 7:149573187 | T/C | 0.09 | 0 | 4.53 | 9.48×10−5 | ATP6V0E2 | 0.34 |
| rs7799802 | 7:149577330 | A/G | 0.09 | 0 | 4.53 | 9.48×10−5 | ATP6V0E2 | 0.35 |
| rs3796547 | 4:57181995 | T/C | 0.50 | 0.24 | 1.75 | 9.58×10−5 | KIAA1211 | 0.69 |
| rs28559894 | 4:57182758 | T/C | 0.50 | 0.24 | 1.75 | 9.58×10−5 | KIAA1211 | 0.66 |
| *prior AMD locus | ||||||||