Molecular Vision: Ren, Mol Vis 2015; 21:948-954. Table 4

Table 4. The frequencies of KIR centromeric (Cen) and telomeric (Tel) gene content motifs in healthy controls and EDE patients.

Motifs^#	Healthy controls		DED patients		OR (95% CI)	p value	P_C (n=6)
Motifs^#	+	gf(%)	+	gf (%)	OR (95% CI)	p value	P_C (n=6)
Centromeric (2DS2, 2DL2, 2DL3)
Cen-A/A	163	74.09	56	70.89	0.85(0.48–1.51)	0.581
Cen-A/B	43	19.55	12	15.19	0.74(0.37–1.48)	0.391
Cen-B/B	14	6.36	11	13.92	2.38(1.03–5.49)	0.037*	﹥0.05
Telomeric (3DL1, 3DS1, 2DS1, 2DS4)
Tel-A/A	149	67.73	51	64.56	0.87(0.51–1.49)	0.608
Tel-A/B	38	17.27	17	21.52	1.31(0.69–2.49)	0.403
Tel-B/B	33	15	11	13.92	0.92(0.44–1.91)	0.817

#: KIR centromeric (Cen) and telomeric (Tel) gene content motifs were defined according to the description of Cooley et al. [8]. Briefly, Cen-A/A contains 2DL3 with 2DS2 and/or 2DL2, and Cen-B/B contains 2DS2 and/or 2DL2 but no 2DL3, whereas Tel-A/A has 3DL1 and 2DS4 only, Tel-A/B has 3DL1 and 2DS4 with 3DS1 and/or 2DS1 and Tel-B/B lacks 3DL1 and/or 2DS4. +, positive numbers; gf, genotype frequency; OR, odds ratio; 95% CI, 95% confidence interval; *, indicates statistical significance (p<0.05) according Chi Square analysis; Pc, corrected p value after Bonferroni correction; ?, unclassed haplotype.