Figure 1. Pedigree of family PKRP133. Squares are males, circles are females, filled symbols are affected individuals, the double line between individuals indicates consanguinity, and the diagonal line through a symbol is a deceased family member. The haplotypes of 14 adjacent chromosome 5q33 microsatellite markers are shown. The alleles that form the risk haplotype are shaded black and the alleles that do not cosegregate with RP are shown in white.