Figure 5. Fraction of retinal ganglion cells responding to a light step in isolated retinas. In both seeing Pde6b⁺ mouse lines, over 90% of the retinal ganglion cells (GCs) responded to light, with no significant difference between the C3H/He-Pde6b⁺ and FVB/N-Pde6b⁺ lines. At 4 weeks, the fraction of responding GCs in the C3H/HeOu mice approximated that of Pde6b⁺ mice, while the number of responding cells in the age-matched FVB/N mice was already significantly reduced. No responding GCs remained in the FVB/N mice at 12 weeks of age compared to the C3H/HeOu mice where retinal responsiveness disappeared only at 24 weeks of age. For each group, n=6 retinas from six different mice.