Table 2 of Guggenheim, Mol Vis 2015; 21:621-632.

Table 2. SNP-heritability (estimates of variance explained by SNPs) for refractive error, at a range of ages.

Research

clinic 
visit		 N Untransformed trait Transformed trait
h2SNP SE p-value h2SNP SE p-value
7 5103 0.250 0.067 9.7e-05 0.342 0.068 1.6e-07
10 4862 0.198 0.069 1.5e-03 0.204 0.069 1.1e-03
11 4433 0.194 0.075 4.0e-03 0.260 0.076 2.0e-04
12 4438 0.270 0.076 1.4e-04 0.323 0.076 5.1e-06
15 3404 0.259 0.097 2.9e-03 0.270 0.096 1.8e-03
Mean   0.233 ~0.08 <0.001 0.281 ~0.08 <0.001

Analyses included sex as a covariate. Estimates are shown for refractive error in Diopters (“untransformed trait”) or after refractive error readings were transformed to normal scores (“transformed trait”). P values correspond to a test of whether the heritability estimate is different from zero. The mean was calculated after weighting by sample size (N), using the formula, Σ(h2N)/ΣN

Guggenheim, Mol Vis 2015; 21:621-632. http://www.molvis.org/molvis/v21/621

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