Table 4 of
Hu, Mol Vis 2015; 21:589-603. Table 4 of
Hu, Mol Vis 2015; 21:589-603.
Table 4. Genotype and allele frequencies of IL10 polymorphisms in BD patients and controls.
| SNPs | study | Allele | Case | Control | P value | Pc value | OR(95%CI) |
|---|---|---|---|---|---|---|---|
| (frequency) | (frequency) | ||||||
| rs1800871 | StageI | C C | 6(0.020) | 44(0.126) | 4.60×10−7 | 8.28×10−6 | 0.142(0.060–0.338) |
| C T | 126(0.420) | 160(0.457) | 0.342 | NS | 0.860(0.630–1.174) | ||
| T T | 168(0.560) | 146(0.417) | 2.80×10−4 | 5.03×10−3 | 1.778(1.302–2.429) | ||
| C | 138(0.230) | 248(0.354) | 1.01×10−6 | 1.82×10−5 | 0.544(0.426–0.696) | ||
| T | 462(0.770) | 452(0.646) | 1.01×10−6 | 1.82×10−5 | 1.837(1.437–2.347) | ||
| StageII | C C | 27(0.065) | 166(0.118) | 0.002 | 0.03 | 0.515(0.337–0.785) | |
| C T | 175(0.419) | 679(0.484) | 0.019 | NS | 0.768(0.616–0.958) | ||
| T T | 216(0.517) | 558(0.398) | 1.55×10−5 | 2.33×10−4 | 1.619(1.300–2.017) | ||
| C | 229(0.274) | 1011(0.360) | 3.73×10−6 | 5.59×10−5 | 0.670(0.565–0.794) | ||
| T | 607(0.726) | 1795(0.640) | 3.73×10−6 | 5.59×10−5 | 1.493(1.259–1.770) | ||
| Combined | C C | 33(0.046) | 210(0.120) | 2.19×10−8 | 3.95×10−7 | 0.354(0.243–0.517) | |
| C T | 301(0.419) | 839(0.479) | 0.007 | NS | 0.786(0.660–0.937) | ||
| T T | 384(0.535) | 704(0.402) | 1.39×10−9 | 2.50×10−8 | 1.713(1.438–2.041) | ||
| C | 367(0.256) | 1259(0.359) | 2.03×10−12 | 3.65×10−11 | 0.613(0.534–0.703) | ||
| T | 1069(0.744) | 2247(0.641) | 2.03×10−12 | 3.65×10−11 | 1.632(1.423–1.872) | ||
| rs1800872 | StageI | A A | 170(0.567) | 140(0.400) | 2.22×10−5 | 4×10−4 | 1.962(1.435–2.682) |
| A C | 120(0.400) | 174(0.497) | 0.013 | NS | 0.674(0.494–0.921) | ||
| C C | 10(0.033) | 36(0.103) | 0.001 | 0.018 | 0.301(0.147–0.617) | ||
| A | 460(0.767) | 454(0.649) | 3.39×10−6 | 6.1×10−5 | 1.780(1.394–2.274) | ||
| C | 140(0.233) | 246(0.351) | 3.39×10−6 | 6.1×10−5 | 0.562(0.440–0.717) | ||
| rs1800896 | StageI | A A | 271(0.903) | 293(0.837) | 0.013 | NS | 1.818(1.129–2.928) |
| A G | 29(0.097) | 56(0.160) | 0.017 | NS | 0.562(0.348–0.906) | ||
| G G | 0(0.000) | 1(0.003) | 0.354 | NS | |||
| A | 57(0.952) | 642(0.917) | 0.013 | NS | 1.779(1.123–2.817) | ||
| G | 29(0.048) | 58(0.083) | 0.013 | NS | 0.562(0.355–0.890) | ||
| rs3021094 | StageI | A A | 58(0.193) | 100(0.286) | 0.006 | NS | 0.599(0.414–0.866) |
| A C | 173(0.577) | 199(0.569) | 0.835 | NS | 1.034(0.757–1.412) | ||
| C C | 69(0.230) | 51(0.146) | 0.006 | NS | 1.751(1.173–2.614) | ||
| A | 289(0.482) | 399(0.570) | 0.001 | 0.018 | 0.701(0.563–0.873) | ||
| C | 311(0.518) | 301(0.430) | 0.001 | 0.018 | 1.426(1.146–1.776) | ||
| rs3790622 | StageI | C C | 260(0.867) | 312(0.891 | 0.333 | NS | 0.792(0.493–1.271) |
| C T | 39(0.130) | 38(0.109) | 0.399 | NS | 1.227(0.762–1.975) | ||
| T T | 1(0.003) | 0(0.000) | 0.280 | NS | |||
| C | 559(0.932) | 662(0.946) | 0.291 | NS | O.783(0.496–1.234) | ||
| T | 41(0.068) | 38(0.054) | 0.291 | NS | 1.278(0.810–2.015) | ||
| rs1554286 | StageI | T T | 168(0.560) | 130(0.371) | 1.51×10−6 | 2.72×10−5 | 2.154(1.572–2.950) |
| C T | 116(0.387) | 181(0.517) | 8.72×10−4 | 0.015687 | 0.589(0.430–0.805) | ||
| C C | 16(0.053) | 39(0.111) | 0.080 | NS | 0.449(0.246–0.822) | ||
| T | 452(0.753) | 441(0.630) | 1.75×10−6 | 3.15×10−5 | 1.794(1.410–2.282) | ||
| C | 148(0.247) | 259(0.370) | 1.75×10−6 | 3.15×10−5 | 0.558(0.438–0.709) |