Figure 1. Pedigrees of 16 Taiwanese families with X-linked retinoschisis and identified mutations in the RS1 gene. Black boxes represent affected males, and arrows point to probands. Circles with a black dot in the center represent carrier females by sequence analysis, while circles with an open dot represent non-tested potential carriers. Mutations of the RS1 gene were screened for all family members except those who did not want to or could not participate in the study. Patient II-1 in Family L was adopted into the family with no previous family history available. Patient II-1 and II-2 in Family M were dizygotic twins.