Figure 2. Schematic representation of factor H and its functional domains. Factor H is composed of 20 complement control protein (CCP)
domains, and the approximate locations of missense variations are indicated at the top of the diagram. The location of the
binding sites for C3b (black), cofactor activity (purple), heparin (orange), sialic acid (green), and self-surface recognition
(blue bars) are mentioned below the diagram.