Figure 5. Effects of CDECM on the mRNA expression patterns of inflammatory factors. A: The mRNA expression in the corneas. B: The mRNA expression in the conjunctivas. Quantitative real-time (qRT)-PCR assessing the expression of the tumor necrosis
factor (TNF-α), matrix metalloproteinase-2 (MMP-2), MMP-9, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion
molecule-1 (VCAM-1) mRNAs in the corneas or conjunctivas of the NOD.B10.H2b mice after the removal of desiccation stress and after 10 days of instillation of PBS or chondrocyte-derived extracellular
matrix (CDECM) five times per day. The quantitative data are presented as mean ± standard deviation (SD). *p<0.05 versus the
value in the DS 10D group. DS 10D, desiccation stress for 10 days; PBS, PBS group after 10 days of instillation; CDECM, CDECM
group after 10 days of instillation.