Figure 1. Effects of CDECM on tear production. Changes in the tear volumes of the experimental PBS- and chondrocyte-derived extracellular matrix (CDECM)-instilled NOD.B10.H2^b mice after the elimination of desiccation stress (DS). PBS or CDECM was instilled five times per day for the indicated number of days, and the tear volumes of the NOD.B10.H2^b mice were measured after 3, 5, 7, and 10 days of instillation. The quantitative data are presented as mean ± standard deviation (SD). *p<0.05 versus the value in the PBS group. #p<0.05 versus the corresponding value in the DS 10 day (10D) group.