Figure 1. Sequencing results of the constitutive causative heterozygous mutations of the RB1 gene. A: c.289G>T, p.Glu97* in pedigree PKRB51. B: c.751C>T, p.Arg251* in pedigree PKRB 40. C: c.967G>T, p.Glu323* in pedigree PKRB22. D: c.772_776del, p.Asn258Glufs*10 in pedigree PKRB44. Abbreviations: FN represents father normal, MN represents other normal, FC represents father carrier, MC mother carrier, NS represents normal sibling