Figure 1. Changes in the intraocular pressure and electroretinogram recordings in glaucomatous and control mice. A: Assessment of intraocular pressure (IOP) measurements in the glaucomatous (DBA/2J) and control (C57) mice as a function of age. Animals were measured at 3, 9, and 15 months of age. A significant increase was observed in DBA/2J mice at 12 months when compared with the control mice (*p<0.05). B: Scotopic threshold responses from control C57BL/6J or DBA/2J glaucomatous mice as a function of age. Superposed averaged positive scotopic threshold response (pSTR) amplitudes were measured from the electroretinogram (ERG) flash response as a function of stimulus light intensity recorded from C57BL/6J (triangles) and DBA/2J (circles) mice at 3 (white symbols), 9 (gray symbols), and 15 months (black symbols). Plot data correspond to mean values ± standard deviation (SD) (n=8). A significant reduction in the STR amplitudes in the DBA/2J mice between 3 and 15 months is observed for pSTR amplitudes (***p<0.001) and when compared with the control mice at 15 months (^$p<0.001).