Figure 2. Nanophthalmos pedigree 951-N from the Marianas Islands. Subjects with nanophthalmos are indicated with black symbols, while healthy subjects are indicated with white symbols. Gray symbols indicate unknown affection status. Diagnosis was made with a clinical exam or a review of the medical records for all available family members. Diagnosis of family members indicated with stars was determined by family history. The subjects who contributed a DNA sample for the study are indicated with an “X.”