Figure 4. Pro- and anti-apoptotic proteins in control, β2KO+49b and β2KO lysates. Proapoptotic (Panels A–B) and antiapoptotic (Panels C–D) in control, β2-adrenergic receptor knockout mice+49b, and β2-adrenergic receptor knockout mice. A–D: Compound 49b reduces proapoptotic protein levels of Bax (A) and cleaved caspase 3 (B), while increasing the antiapoptotic proteins Bcl-xL (C) and phosphorylated Akt (D). *p<0.05 versus wild-type (WT); #p<0.05 versus β2-adrenergic receptor knockout (KO) mice. n = 5 for all groups. Data are mean ± standard error of the mean (SEM).