Figure 2. Tumor necrosis factor α and insulin-receptor substrate 1^Ser307 phosphorylation in control, β2-adrenergic receptor knockout mice+49b and β2-adrenergic receptor knockout mice. A: Tumor necrosis factor α (TNF-α) levels are returned to near control levels in β2-adrenergic receptor knockout (KO) mice treated with Compound 49b. B: Similar results for the phosphorylation of serine 307 on insulin-receptor substrate 1 (IRS-1). *p<0.05 versus wild-type (WT); #p<0.05 versus β2-adrenergic receptor KO mice. n = 5 for all groups. Data are mean ± standard error of the mean (SEM).