Table 4 of
Emam, Mol Vis 2014; 20:804-811. Table 4 of
Emam, Mol Vis 2014; 20:804-811.
Table 4. Genotype and allele distributions of polymorphisms of endothelial nitric oxide synthase (NOS3) gene in high-tension primary open-angle glaucoma patients and controls in Egyptians.
| Parameters | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases; n=76 | Controls; n=56 | Odds ratio (95%CI) | P value* | Cases; n=84 | Controls; n=54 | Odds ratio (95%CI) | P value* | |
| NOS3 T-786C (rs2070744) | ||||||||
| TT | 32 (42.1%) | 30 (53.6%) | Reference | – | 31 (36.9%) | 30 (55.6%) | Reference | – |
| TC | 26 (34.2%) | 19 (33.9%) | 1.01 (0.49–2.10) | 0.97 | 33 (39.3%) | 19 (35.2%) | 1.19 (0.59–2.42) | 0.63 |
| CC | 18 (23.7%) | 7 (12.5%) | 2.17 (0.84–5.63) | 0.11 | 20 (23.8%) | 5 (9.3%) | 3.06 (1.07–8.74) | 0.03 |
| T allele | 90 (59.2%) | 79 (69.6%) | Reference | – | 95 (57.6%) | 79 (73.1%) | Reference | – |
| C allele | 62 (40.8%) | 33 (30.4%) | 1.65 (0.98–2.77) | 0.06 | 73 (43.5%) | 29 (26.9%) | 2.09 (1.24–3.53) | 0.005 |
| NOS3 Glu298Asp (rs1799983) | ||||||||
| Glu/Glu | 41 (53.9%) | 32 (57.1%) | Reference | – | 40 (46.6%) | 31 (57.4%) | Reference | – |
| Glu/Asp | 24 (31.6%) | 19 (33.9%) | 0.90 (0.43–1.87) | 0.78 | 35 (41.7%) | 18 (33.3%) | 1.43 (0.70–2.91) | 0.33 |
| Asp/Asp | 11 (14.5%) | 5 (8.9%) | 1.73 (0.56–5.28) | 0.33 | 9 (10.7%) | 5 (9.3%) | 1.18 (0.37–3.72) | 0.78 |
| Glu allele | 106 (69.7%) | 83 (74.1%) | Reference | – | 115 (68.5%) | 80 (74.0%) | Reference | – |
| Asp allele | 46 (30.3%) | 29 (25.9%) | 1.24 (0.72–2.14) | 0.44 | 53 (31.6%) | 28 (26.0%) | 1.32 (0.77–2.26) | 0.32 |
| Intron 4 polymorphism of NOS3 | ||||||||
| b/b | 53 (69.7%) | 38 (67.9%) | Reference | – | 57 (67.9%) | 32 (59.3%) | Reference | – |
| b/a | 18 (23.7%) | 14 (25.0%) | 0.93 (0.42–2.08) | 0.86 | 23 (27.4%) | 18 (33.3%) | 0.75 (0.36–1.58) | 0.46 |
| a/a | 5 (6.6%) | 4 (7.1%) | 0.92 (0.23–3.58) | 0.90 | 4 (4.8%) | 4 (7.4%) | 0.63 (0.15–2.61) | 0.52 |
| b allele | 124 (81.6%) | 90 (80.3%) | Reference | – | 137 (81.6%) | 82 (75.9%) | Reference | – |
| a allele | 28 (18.4%) | 22 (19.6%) | 0.92 (0.50–1.72) | 0.80 | 31 (18.5%) | 26 (24.1%) | 0.71 (0.40–1.29) | 0.26 |