Table 3 of
Emam, Mol Vis 2014; 20:804-811. Table 3 of
Emam, Mol Vis 2014; 20:804-811.
Table 3. Genotype and allele distributions of polymorphisms of endothelial nitric oxide synthase (NOS3) gene* in primary high-tension open-angle glaucoma patients (n=160) and controls (n=110) in Egyptians.
| Genotype | Patients, No (%) | Controls, No (%) | Odds ratio (95%CI) | P value** |
|---|---|---|---|---|
| NOS3 T-786C (rs2070744) | ||||
| TT | 63 (39.4) | 60 (54.5) | 1 (reference) | – |
| TC | 59 (36.9) | 38 (34.5) | 1.11 (0.67–1.84) | 0.70 |
| CC | 38 (23.8) | 12 (10.9) | 2.54 (1.26–5.13) | 0.007 |
| T allele | 185 (57.8) | 158 (71.8) | 1 (reference) | <0.001 |
| C allele | 135 (42.2) | 62 (28.2) | 1.86 (1.29–2.69) | |
| NOS3 Glu298Asp (rs1799983) | ||||
| Glu/Glu | 81 (50.6) | 63 (57.3) | 1 (reference) | – |
| Glu/Asp | 59 (36.9) | 37 (33.6) | 1.15 (0.69–1.92) | 0.58 |
| Asp/Asp | 20 (12.5) | 10 (9.1) | 1.43 (0.64–3.18) | 0.38 |
| Glu allele | 221 (69.1) | 163 (74.1) | 1 (reference) | 0.21 |
| Asp allele | 99 (30.9) | 57 (25.9) | 1.28 (0.87–1.88) | |
| Intron 4 polymorphism of NOS3 | ||||
| b/b | 110 (68.8) | 70 (63.6) | 1 (reference) | – |
| b/a | 41 (25.6) | 32 (29.1) | 0.84 (0.49–1.45) | 0.53 |
| a/a | 9 (5.6) | 8 (7.3) | 0.76 (0.28–2.03) | 0.58 |
| b allele | 261 (81.6) | 172 (78.2) | 1 (reference) | 0.33 |
| a allele | 59 (18.4) | 48 (21.8) | 0.81 (0.53–1.24) | |