Figure 6. Effect of Cx43 downregulation on retinal thickness. Representative optical coherence tomography scans indicate increased retinal thickness in the diabetic rats and those injected with Cx43 siRNA compared to the non-diabetic or scrambled siRNA-injected control rats. Retinal thickness assessment around the midretina was made from the (A) non-diabetic control rats, (B) diabetic rats, (C) non-diabetic rats intravitreally injected with Cx43 siRNA, and (D) non-diabetic rats intravitreally injected with scrambled siRNA. Graphical illustration of cumulative data indicates significant overall thickening in the retinas of the diabetic rats and the rats injected with Cx43 siRNA compared to those of the control rats. Data are presented as mean ± SD (*p<0.05, n=4).