Table 3 of
Querques, Mol Vis 2014; 20:575-592. Table 3 of
Querques, Mol Vis 2014; 20:575-592.
Table 3. Changes in mean measurements and in specific features in patients with Best vitelliform macular dystrophy by categorizing the stage of the disease at study entry.
| Previtelliform (n=11)FU: 34.3±19.7 months | Study entry | Last visit | p |
|---|---|---|---|
| BCVA (LogMAR) | 0.02±0.06 | 0.02±0.06 | 1 |
| FAF fovea (n) | Iso=9 Hyper=2 | Iso=9 Hyper=2 | 1 |
| EZ status (n) | Normal=11 | Normal=11 | 1 |
| OCT reflectivity (n) | Hyper=11 | Hyper=11 | 1 |
| CMT (μm) | 256.4±26.6 | 247.5±21.8 | 0.3 |
| Vitelliform (n=1) FU: 61 months | Study entry | Last visit | |
| BCVA (LogMAR) | 0.4 | 0.4 | 1 |
| Overall lesion area (mm2) | 0.28 | 0.36 | 0.9 |
| Hyperautofluorescent component of the lesion (mm2) | 0.28 | 0.36 | 0.9 |
| Hypoautofluorescent component of the lesion (mm2) | 0 | 0 | 1 |
| FAF fovea | Hyper | Hyper | 1 |
| EZ status fovea | Normal | Normal | 1 |
| OCT reflectivity | Hyper | Hyper | 1 |
| Maximal OCT lesion thickness (μm) | 175 | 210 | 0.8 |
| Maximal OCT lesion width (μm) | 601 | 687 | 0.8 |
| OCT neurosensory retinal thickness fovea (μm) | 88 | 90 | 0.9 |
| CMT (μm) | 278 | 310 | 0.8 |
| Pseudohypopyon (n=6) FU: 49.1±24.7 months | Study entry | Last visit | p |
| BCVA (LogMAR) | 0.31±0.3 | 0.27±0.1 | 0.6 |
| Overall lesion area (mm2) | 5.96±2.9 | 6.30±3.3 | 0.7 |
| Hyperautofluorescent component of the lesion (mm2) | 2.82±2.6 | 2.37±2.1 | 0.009 |
| Hypoautofluorescent component of the lesion (mm2) | 3.22±1.8 | 4.81±2.0 | 0.01 |
| FAF fovea (n) | Hypo=6 | Hypo=6 | 1 |
| EZ status fovea (n) | Normal=2 / Disrupted=4 | Disrupted=6 | 0.8 |
| OCT reflectivity (n) | Mixed=6 | Mixed=3 Hypo=3 | 0.7 |
| Maximal OCT lesion thickness (μm) | 288.5±57.2 | 243.6±60.4 | 0.09 |
| Maximal OCT lesion width (μm) | 2510±895.9 | 2381.4±780.9 | 0.2 |
| OCT neurosensory retinal thickness fovea (μm) | 93.5±30.4 | 89.2±8.6 | 0.09 |
| CMT (μm) | 392.0±53.7 | 362.0±70.0 | 0.1 |
| Vitelliruptive (n=8)FU: 45.1±17.6 months | Study entry | Last visit | p |
| BCVA (LogMAR) | 0.25±0.16 | 0.24±0.34 | 0.6 |
| Overall lesion area (mm2) | 4.99±3.5 | 5.38±3.5 | 0.7 |
| Hyperautofluorescent component of the lesion (mm2) | 0 | 1.20±2.4 | 0.02 |
| Hypoautofluorescent component of the lesion (mm2) | 4.99±3.5 | 4.28±1.8 | 0.6 |
| FAF fovea (n) | Hypo=8 | Hypo=8 | 1 |
| EZ status fovea (n) | Disrupted=8 | Disrupted=8 | 1 |
| OCT reflectivity (n) | Hypo=3 / Mixed=5 | Mixed=8 | 0.7 |
| Maximal OCT lesion thickness (μm) | 238.8±89.9 | 198.8±102.3 | 0.5 |
| Maximal OCT lesion width (μm) | 2285.33±737.5 | 1907.75±579.2 | 0.3 |
| OCT neurosensory retinal thickness fovea (μm) | 104.16±45.6 | 84.75±17.3 | 0.4 |
| CMT (μm) | 365.0±47.5 | 379.62±55.8 | 0.5 |
| Atrophic (n=4)FU: 31.0±8.0 months | Study entry | Last visit | p |
| BCVA (LogMAR) | 0.75±0.33 | 0.75±0.33 | 1 |
| Overall lesion area (mm2) | 3.72±2.5 | 3.70±2.9 | 0.2 |
| Hyperautofluorescent component of the lesion (mm2) | 1.49±2.1 | 1.49±2.1 | 1 |
| Hypoautofluorescent component of the lesion (mm2) | 2.23±2.2 | 2.21±2.8 | 0.3 |
| FAF fovea (n) | Hypo 4 | Hypo 4 | 1 |
| EZ status fovea (n) | Absent 4 | Absent 4 | 1 |
| Maximal OCT lesion width (μm) | 1966.75±596.9 | 2012.75±528.4 | 0.5 |
| OCT neurosensory retinal thickness fovea (μm) | 60.2±5.6 | 54.5±12.8 | 0.6 |
| CMT (μm) | 168.0±34.5 | 163.5±39.5 | 0.5 |
| Fibrotic (n=11)FU: 41.7±16.8 months | Study entry | Last visit | p |
| BCVA (LogMAR) | 0.60±0.32 | 0.55±0.30 | 0.3 |
| Overall lesion area (mm2) | 8.59±5.3 | 8.57±6.2 | 0.7 |
| Hyperautofluorescent component of the lesion (mm2) | 5.41±2.3 | 5.42±2.0 | 0.9 |
| Hypoautofluorescent component of the lesion (mm2) | 3.18±1.0 | 3.15±1.2 | 0.8 |
| FAF fovea (n) | Hypo=11 | Hypo=11 | 1 |
| EZ status fovea (n) | Absent=9 /Disrupted=2 | Absent=9 /Disrupted=2 | 1 |
| OCT reflectivity (n) | Mixed=11 | Mixed=11 | 1 |
| Maximal OCT lesion thickness (μm) | 354.6±191.6 | 348.8±190.9 | 0.8 |
| Maximal OCT lesion width (μm) | 2788.4±832.4 | 2721.2±864.0 | 0.7 |
| OCT neurosensory retinal thickness fovea (μm) | 104.7±63.8 | 98.8±41.9 | 0.1 |
| CMT (μm) | 458.3±249.7 | 457.2±245.2 | 0.2 |