Table 6 of Zhang, Mol Vis 2014; 20:56-72.

Table 6. Selected under-expressed Smarca4-regulated RPE genes that were not differentially expressed in the retina revealed potential biologic insights on the morphological defects.

Biological comparison Potentially relevant biologic functions
Smarca4/WT RPE expression fold change* Cytoskeletal dynamics/ melanosomes formation/ membrane trafficking Secreted/extracellular signals Intracellular signal transducers Other
<1 (under-expressed in smarca4 RPE) si:ch211–87l2.1, fancl, magi2, map2k1, myl12.2, nav2b, pacrg, pdcl3, ppp1r12a, sec23ip, smarca2, tubb5 adam9, bmp8a, gdnf ghdc, guk1a, gsk3b, map2k1, ppp1r12a, spdya, tcf7l1a phyh

A literature search was conducted on the 39 Smarca4-regulated RPE genes to gain insights into their potential roles in smarca4 RPE/retinal development. Several genes that were under-expressed in the smarca4 RPE have related functional roles in cytoskeletal dynamics, melanogenesis, paracrine and/or intracellular signaling; and the relevance of these functions is elaborated in the discussion section. Some of these genes are listed under different categories as they have multiple functional roles.

Zhang, Mol Vis 2014; 20:56-72. http://www.molvis.org/molvis/v20/56

©2014 Molecular Vision http://www.molvis.org/molvis/

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